|
发表于 2022-9-17 19:56:51
|
显示全部楼层
While not every biosynthesis intermediate has been isolated, radiolabel incorporation experiments with malonate and acetate subunits showed that the tetracycline ring system is formed through addition of malonylamyl- CoA and acetyl- CoA units Figure 4, I to form a linear nona or decaketide precursor II, followed by a concerted series of enzyme- mediated foldings, and ring closures and stereochemical transformations by type II polyketide synthases, forming the basic naphthacene ring system. <a href=http://buydoxycyclineon.com/>doxycycline for</a> |
|